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pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can cut down panobinostat ranges by ~70% and result in procedure failure.pentobarbital will lessen the level or effect of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use A